Research shows that just over 50% of children on the ketogenic diet will have 50% or more improvement in seizures2. About 1/3 of children will have over 90% improvement in seizures and about 10-15% will become seizure-free. When dietary therapy is effective in controlling seizures, anticonvulsant medication can sometimes be reduced3 or even discontinued entirely4. Many parents also report improved development and behavior.
The ketogenic ratio refers to the ratio of the grams of fat to the grams of protein and carbohydrate in the diet. The healthcare provider determines which ratio is most appropriate for each patient. The traditional ketogenic diet is usually a 4:1 ratio, however, adolescents and children under the age of 2 are often started on a 3:1 ratio to allow for more protein in the diet1. A ketogenic diet at a 4:1 ratio is 90% fat, while a diet at a 3:1 ratio is 87% fat.
On a typical diet, the body primarily uses glucose (carbohydrate) for energy. The ketogenic diet works by shifting the body's metabolism from using glucose for energy to using mostly fat for energy, which produces biochemical changes in the body, and for some people, reduces seizures.
In cases when the diet is effective, it is generally used for at least 2 years5. After this time, the healthcare provider may recommend weaning off the diet. Many children are able to come off the diet without worsening of seizures.
The ketogenic diet is effective in different kinds of seizures and is not limited to any one type of epilepsy. However, research suggests that the ketogenic diet may be particularly beneficial for patients with infantile spasms, myoclonic-astatic epilepsy (aka Doose syndrome), Rett syndrome, Glut-1 deficiency syndrome, tuberous sclerosis complex, Dravet syndrome and children on a formula-only ketogenic diet, taken orally or through a feeding tube6.
There are side effects associated with a ketogenic diet, which is why it should only be done under medical supervision. The most commonly reported side effects are gastrointestinal disturbances such as constipation, nausea, vomiting, or diarrhea7. Consult with your child's healthcare provider to learn more about potential side effects.
1 Kossoff EH, Freeman J, Turner Z, Rubenstein J. Ketogenic Diets: Treatments for Epilepsy and Other Disorders; Fifth Edition. Demos Health Publishing, NY, NY, 2011.
2 Freeman JM, et al. The efficacy of the ketogenic diet-1998: a prospective evaluation of intervention in 150 children. Pediatrics. 1998 Dec;102(6):1358-63.
3 Kossoff EH, Pyzik PL, McGrogan JR, et al. Impact of early versus late anticonvulsant reduction after ketogenic diet initiation. Epilepsy and Behav 2004;5:499-502.
4 Gilbert DL, Pyzik PL, Vining EP, et al. Medication cost reduction in children on the ketogenic diet: data from a prospective study. J Child Neurol 1999;14:469-471.
5 Martinez CC, Pyzik PL, Kossoff EH. Discontinuing the ketogenic diet in seizure-free children: recurrence and risk factors. Epilepsia. 2007 Jan;48(1):187-90.
6 Kossoff EH, Zupec-Kania BA, Amark PE, et al. Optimal clinical management of children receiving the ketogenic diet: recommendations of the international ketogenic diet study group. Epilepsia. 2009;50(2):304-317.
7 Kang HC, Chung DE, Kim DW, Kim HD. Early- and late-onset complications of the ketogenic diet for intractable epilepsy. Epilepsia. 2004 Sep;45(9):1116-23.